Research Paper Details
Paper Abstract
Very low vitamin D levels have been noted in patients with a variety of autoimmune diseases.
To determine whether low vitamin D levels are associated with autoimmunity in the setting of vitiligo vulgaris.
A prospective cohort study was conducted on 45 consecutive patients with vitiligo vulgaris. 25-Hydroxyvitamin D levels were determined from sera collected at the time of study enrollment. Logistic regression analysis of the relationship of 25-hydroxyvitamin D levels to disease state was performed, including surface area, recent-onset vitiligo, Fitzpatrick skin type and ethnicity, dairy intake, and both personal and family history of autoimmunity. Multiple univariate and multivariate logistic regression models were developed to assess the interrelationship of these parameters.
25-Hydroxyvitamin D levels were divided into 3 groups: 31.1% were normal (>30 ng/mL), 55.6% were insufficient (<30 ngml), and 13.3% were very low (<15 ml).insufficient 25-hydroxyvitamin d levels associated with increasing fitzpatrick phototypes (odds ratio [or] =1.76, 95% confidence interval [ci] =1.12-2.77). comorbid autoimmune illness (or =10.00, ci =1.06-94.7), but not age, gender, race ethnicity, family history of vitiligo or disease, new-onset body surface areaaffected. none the surveyed patients reported daily vitamin intake greater than 200 iu.
This study consists of a small cohort that assesses point prevalence without assessing seasonal variation in vitamin D levels.
Very low 25-hydroxyvitamin D levels (<15 ngml) appear to be a reasonable screening tool for the presence of comorbid autoimmunity. furthermore, we demonstrate that fitzpatrick phototype, rather than ethnicity, is specifically associated with 25-hydroxyvitamin d levels are insufficient (<30 ml).
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